Mac and Cheese Meatloaf Casserole Recipe
Introduction
Mac and Cheese Meatloaf Casserole is a comforting twist on two classic family favorites. This hearty dish layers seasoned meatloaf with creamy macaroni and cheese, creating a satisfying meal that’s perfect for any night of the week. Easy to prepare and full of rich flavors, it’s sure to become a new household staple.

Ingredients
- 1 lb ground beef
- 2 cups uncooked macaroni
- 2 cups shredded cheddar cheese
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk (for meatloaf)
- 2 tbsp butter (for cheese sauce)
- 2 cups milk (for cheese sauce)
- 1 tsp salt
- 1/2 tsp pepper
- 1/2 tsp paprika
- 1/2 tsp dry mustard
- 2 tbsp flour
Instructions
- Step 1: Preheat your oven to 350°F (175°C).
- Step 2: In a mixing bowl, combine ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, 1 tsp salt, and 1/2 tsp pepper. Mix well and press the mixture into a greased baking dish to form the meatloaf layer.
- Step 3: Bake the meatloaf for 20 minutes.
- Step 4: While the meatloaf bakes, cook the macaroni according to the package directions. Drain and set aside.
- Step 5: To make the cheese sauce, melt butter in a saucepan over medium heat. Stir in the flour and cook for one minute until it forms a smooth paste.
- Step 6: Gradually whisk in 2 cups milk, stirring continuously until the sauce thickens. Season with 1/2 tsp salt, 1/2 tsp pepper, paprika, and dry mustard. Stir in the shredded cheddar cheese until melted and smooth.
- Step 7: Mix the cooked macaroni with the cheese sauce, then pour this mixture evenly over the partially baked meatloaf layer. Sprinkle with the remaining shredded cheese on top.
- Step 8: Bake the casserole for an additional 25 minutes, or until it is bubbly and the cheese is golden.
Tips & Variations
- Use sharp cheddar or a blend of cheeses like mozzarella and gouda for extra flavor and creaminess.
- Add finely chopped bell peppers or mushrooms to the meatloaf mix for added texture and nutrition.
- For a spicier version, include a pinch of cayenne pepper or chopped jalapeños in the cheese sauce.
- Replace ground beef with ground turkey or chicken for a leaner option.
Storage
Store any leftovers covered in the refrigerator for up to 3 days. Reheat individual portions in the microwave or warm the entire casserole in an oven preheated to 350°F (175°C) until hot and bubbly. For longer storage, you can freeze the casserole for up to 2 months; thaw overnight in the refrigerator before reheating.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I make this casserole ahead of time?
Yes, you can assemble the casserole in advance and keep it covered in the refrigerator for up to 24 hours before baking. This makes it ideal for meal prep and busy weeknights.
Can I use gluten-free ingredients?
Absolutely. Use gluten-free breadcrumbs and flour to make this dish suitable for gluten-sensitive diets. There are many good gluten-free pasta options available as well.
PrintMac and Cheese Meatloaf Casserole Recipe
This Mac and Cheese Meatloaf Casserole is a comforting and hearty dish combining savory ground beef meatloaf with creamy macaroni and cheese. Baked together in one casserole, it offers a delicious blend of tender meat, cheesy pasta, and a flavorful sauce perfect for a family dinner or casual gathering.
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: 6 servings 1x
- Category: Casserole
- Method: Baking
- Cuisine: American
Ingredients
Meatloaf
- 1 lb ground beef
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk
- 1 tsp salt
- 1/2 tsp pepper
Macaroni
- 2 cups uncooked macaroni
Cheese Sauce
- 2 tbsp butter
- 2 tbsp flour
- 2 cups milk
- 1 tsp salt
- 1/2 tsp pepper
- 1/2 tsp paprika
- 1/2 tsp dry mustard
- 2 cups shredded cheddar cheese
Instructions
- Preheat Oven: Preheat your oven to 350°F (175°C) to ensure it is at the right temperature for baking the casserole.
- Prepare Meatloaf Mixture: In a mixing bowl, combine the ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, salt, and pepper. Mix thoroughly until all ingredients are well incorporated. Press the mixture firmly into a greased baking dish to form the meatloaf base.
- Bake Meatloaf Base: Place the baking dish in the oven and bake the meatloaf layer for 20 minutes to begin cooking the beef.
- Cook Macaroni: While the meatloaf bakes, cook the macaroni according to package directions until al dente. Drain well and set aside.
- Make Cheese Sauce: In a saucepan over medium heat, melt the butter. Stir in the flour and cook for about one minute to form a roux. Gradually whisk in 2 cups of milk, stirring constantly until the sauce thickens. Season with salt, pepper, paprika, and dry mustard. Remove from heat and stir in 2 cups of shredded cheddar cheese until fully melted and smooth.
- Combine Macaroni and Cheese Sauce: Mix the cooked macaroni with the cheese sauce thoroughly.
- Add Macaroni Cheese Over Meatloaf: Pour the macaroni and cheese mixture evenly over the partially baked meatloaf layer. Sprinkle any remaining shredded cheddar cheese on top for extra cheesiness.
- Bake Casserole: Return the dish to the oven and bake for an additional 25 minutes or until the top is bubbly and the casserole is heated through.
Notes
- Ensure the meatloaf layer is pressed firmly to help it hold its shape during baking.
- Use freshly shredded cheddar cheese for better melting and flavor.
- You can use whole wheat macaroni to add more fiber to the dish.
- Let the casserole rest for 5 minutes after baking before serving to allow it to set.
- Adjust seasoning in the cheese sauce to taste, especially salt and pepper.
Keywords: mac and cheese, meatloaf casserole, comfort food, baked casserole, ground beef recipe, cheesy pasta, family dinner

